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This is how the Russian Sputnik V vaccine applied in Mexico works in your body

In Mexico City, adults over 60 years of age in the Iztacalco, Tláhuac and Xochimilco mayors will receive the Russian Sputnik V vaccine starting on February 25.

The National Vaccination Plan in Mexico will continue with the arrival to the national territory of the first shipment with 400 thousand doses of Sputnik V, the Russian vaccine developed by the Gamaleya National Center for Epidemiology and Microbiology.

After the developments of Pfizer and AstraZeneca, Sputnik V will be the third vaccine which will be applied in the country, after being approved for emergency use on February 2 by the Federal Commission for Protection against Sanitary Risks (COFEPRIS).

How does the Sputnik V vaccine work in your body?

Photo: Alexis Lloret / .)

In the same way as the Oxford and AstraZeneca vaccine, Sputnik V is based on an attenuated adenovirus vector (the virus that causes the common cold in humans), a technique widely used in vaccine development around the world.

The Russian vaccine also consists of two doses, with 21 days of separation between the two to reach the 92% efficient demonstrated in phase 3 clinical trials in more than 20,000 people, including older adults.

Nevertheless, Sputnik V is the first vaccine to be based on two vectors, that is, each dose has a weakened variant of adenovirus (Ad26 and Ad5). These vectors they are not dangerous to the human body, because they were modified to prevent their reproduction and at the same time, to function as a conveyance that will carry a part of the Covid-19 genetic material to the cells.

Sputnik VSource: Sputnik V

After receiving the vaccine in the arm, these adenovirus vectors with coronavirus genetic material inside them penetrate human cells and allow them to ‘read’ the coronavirus protein S gene.

So, “the immune system of the person who has been vaccinated recognizes this protein as foreign and will remember it. If that person becomes infected with SARS-CoV-2, the immune system will destroy the viruses, preventing the development of the disease “, explain Matilde Cañelles López and María Mercedes Jiménez Sarmiento, scientists from the Higher Council for Scientific Research at The Conversation.

In short, the vaccine provides all the necessary information to the immune system to know the mechanism that SARS-CoV-2 uses to produce an infection and respond effectively if it finds the real virus.

Two injections, a blue bottle and a red bottle

Photo: Patricio Murphy / SOPA Images / LightRocket via .

Due to the two adenovirus vectors, the first dose of Sputnik V is different from the first. So once you are about to get vaccinated, make sure that in your first dose you receive the active of jar with blue lid and in the second, the jar with red cap.

Although at the beginning the guidelines of the Gamaleya National Center for Epidemiology and Microbiology explained that Sputnik V required a cold chain below -18ºC to stay in optimal conditions, the manufacturer determined in January 2021 that during transport and storage, stable between 2 and 8ºC, so it can also be stored in a conventional refrigerator.

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