Health.-Acid reflux disease can increase the risk of cancer of the larynx and esophagus

11/15/2019 Heart attack, chest pain.  INTERMOUNTAIN HEALTHCARE HEALTH 11/15/2019 Heart attack, chest pain. INTERMOUNTAIN HEALTHCARE HEALTH


The results of a large prospective study indicate that gastroesophageal reflux disease (GERD), which also causes heartburn symptoms, is linked to an increased risk of various cancers of the larynx and esophagus as published online in CANCER, the journal peer-reviewed by the American Cancer Society.

GERD, a gastrointestinal disorder that affects about 20 percent of adults, occurs when acid from the stomach backs up into the esophagus, where it can cause tissue damage. Research indicates that this damage can put patients at risk for developing a type of cancer called adenocarcinoma of the esophagus.

To provide additional information on this link and potential links to other cancers, a team led by Christian C. Abnet of the National Cancer Institute, part of the National Institutes of Health (NIH) in the United States, examined information on 490,605 adults enrolled in the NIH-AARP Diet and Health Study, a prospective study that mailed questionnaires in 1995-1996 to 3.5 million members of AARP (an American NGO dedicated to people over 50 years old) and 71 years.

Using data from Medicare claims, the researchers estimated that 24 percent of the participants had a history of GERD. Over the next 16 years after participants joined the study, 931 patients developed adenocarcinoma of the esophagus, 876 developed squamous cell carcinoma of the larynx, and 301 developed squamous cell carcinoma of the esophagus.

People with GERD had about twice the risk of developing each of these cancers, and the elevated risk was similar in groups classified by sex, smoking, and alcohol use. The researchers were able to replicate the results when they restricted the analyzes to the Medicare data subset of 107,258 adults.

The team calculated that about 17 percent of these cancers in the larynx and esophagus are associated with GERD.

“This study alone is not sufficient to result in specific actions by the public. Additional research is needed to replicate these findings and establish GERD as a risk factor for cancer and other diseases,” warns Dr. Christian C Study author Abnet – Future studies are needed to assess whether treatments targeting GERD symptoms will alter apparent risks. ”