Researchers from the La Jolla Institute of Immunology (United States), the University of Liverpool and the University of Southampton (United Kingdom) have developed a study in which they have concluded that People who have suffered from severe coronavirus cases could have more T lymphocytes, cells that are crucial in the immunization process of organisms.
The co-director of the study, Pandurangan Vijayanand, confirms this conclusion in his publication in the scientific journal Science Immunology. “The data show that patients who have suffered severe cases of coronavirus would have a greater immunity against future and hypothetical reinfections”, indicates.
However, this was not the initial hypothesis. The scientists hoped to find more CD8 + T lymphocytes in patients with mild symptoms of the disease, as the body had not had to cope with the serious symptoms of the virus. But the more than 80,000 cells analyzed by a single cell transcriptomic analysis of 49 people showed the opposite.
For the study, samples of 39 patients who had suffered coronavirus and 10 who had not. In fact, the latter were collected before the pandemic. Of the 39 sick patients, 17 did not require hospitalization, 13 were admitted to conventional beds and 9 to Intensive Care Units.
The most consistent responses on CD8 + T cells were those of the sickest patients. Therefore, the researchers want to pay attention to see what happens to the lymphocytes of patients with mild symptoms, since their cells suffer a “depletion” justified by the high stimulation received by the immune system in the face of SARS-CoV-2 attacks. “It is important to analyze this depletion, as it could hamper an organism’s ability to create long-term immunity to disease.”
What are CD8 + T lymphocytes?
The so-called cytotoxic T lymphocytes (CD8 T) play a key role in the protection of an individual against external pathogens. For them to come into play they have to be activated by cells infected by the virus. Once they begin to function, they are responsible for replicating memory cells that They allow you to recognize the virus that has infected the body once it tries to enter again and prevent reinfection.