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Chinese vaccine against covid-19 considered safe

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. – A mid-stage trial shows that a Chinese-made COVID-19 vaccine appears to be safe, according to a study published Tuesday in the scientific journal Lancet Infectious Diseases.

Sinovac, the Chinese company that makes the Coronavac vaccine candidate, tested it in a randomized controlled trial involving 700 healthy adult volunteers between April and May. None of the volunteers had a history of COVID-19 infection. None had traveled to areas with a high rate of the disease.

Volunteers in the Phase 2 trial were divided into three groups. One group received a low dose of the vaccine, another received a higher dose, and a third received a placebo.

This particular vaccine uses a chemically inactivated whole virus based on a sample taken from a patient in China. Most other coronavirus vaccines in development use biotechnological approaches to produce just a fragment of the virus. Whole Killed Virus is an old, tried and true method that slows vaccine production and has more side effects, according to doctors.

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The results of the trial on the Chinese vaccine against covid-19

The vaccine was well tolerated at all dose levels and there did not appear to be any safety concerns, according to the researchers, who include experts from the Jiangsu Provincial Center for Disease Control and Prevention, the National Institutes for Food and Drug Control. from China and Sinovac.

The most common complaint was pain at the injection site. One volunteer in the high-dose group had a severe allergic reaction within 48 hours of the first dose, which the researchers said could be related to the vaccine, but the volunteer was treated for the reaction and recovered within three days. The same volunteer did not have a similar allergic reaction on the second dose.

Even at the lowest dose, the volunteers who received the vaccine appeared to show a strong antibody response within 14 days of the second of two injections. Injections were given 14 days apart.

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What about the efficacy of the Chinese vaccine?

The levels of antibodies produced by the vaccination were lower than in volunteers who were infected with COVID-19 and had recovered during the trial, but the researchers said they still hoped it could provide protection. The study was not designed to determine how effective the vaccine was.

This vaccine may have advantages, according to a researcher who worked at the company that made it. This vaccine only needs standard refrigeration. It can also remain stable for up to three years in storage.

The company is continuing its tests to determine how effective the vaccine is.